parkinson's disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3464	PHCCC	(-) PHCCC	GluR
	PHCCC ((-) PHCCC) is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.		GluR
T1880	P7C3		Others
	The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be...		Others
T2216	Entacapone	OR-611	Transferase
	Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).		Transferase
T7729	PF-06454589		LRRK2
	PF-06454589 is a potent inhibitor of LRRK2.		LRRK2
T1770	GNE-9605		LRRK2
	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).		LRRK2
T6795	Carbidopa	(S)-(-)-Carbidopa,Lodosyn	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.		Decarboxylase , Aryl Hydrocarbon Receptor
T4473	Ibiglustat	Venglustat,SAR402671,GZ402671	Transferase
	Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthe...		Transferase
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T8737	GR 125743		5-HT Receptor
	GR 125743 is a novel antagonist of 5-HT1B/1D receptor.		5-HT Receptor
T6726	VU0361737	ML-128,VU 0361737	GluR
	VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of mGlu4 receptor.The EC50 of VU 0361737 is 240 nM for the human receptors. The EC50 of VU 0361737 is110 nM for rat receptors.It exhibits weak activity...		GluR
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T1476	Pramipexole	SND 919	Dopamine Receptor
	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not...		Dopamine Receptor
T3053	CZC-25146	CHEMBL2397014	LRRK2
	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.		LRRK2
T9235	GW604714X	2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-	Mitochondrial Metabolism
	GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate		Mitochondrial Metabolism
T2148	Carbidopa monohydrate	Carbidopa Hydrate,S(-)-Carbidopa	Decarboxylase , Aryl Hydrocarbon Receptor
	Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.		Decarboxylase , Aryl Hydrocarbon Receptor
T0437	Inosine	INO 495,NSC 20262	ROS , Endogenous Metabolite , Adenosine Receptor
	Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.		ROS , Endogenous Metabolite , Adenosine Receptor
T4979	Procyclidine hydrochloride	(±)-Procyclidine hydrochlorid	NMDAR , iGluR
	Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) is a potent anticholinergic agent and also have NMDA antagonist properties.		NMDAR , iGluR
T3217	PF-CBP1 hydrochloride	PF-CBP1 HCl	Epigenetic Reader Domain , Histone Acetyltransferase
	PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.		Epigenetic Reader Domain , Histone Acetyltransferase
T2226	Pergolide mesylate	Pergolide mesylate salt,LY127809,Pergolide methanesulfonate	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Pergolide mesylate salt(LY127809) is a long-acting dopamine agonist which has been used to treat PARKINSON DISEASE and HYPERPROLACTINEMIA but withdrawn from some markets due to potential for HEART VALVE DISEASES.		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T2592	Ropinirole hydrochloride	SKF 101468 hydrochloride,SKF-101468A,Ropinirole HCl	Dopamine Receptor
	Ropinirole hydrochloride (SKF-101468A) is a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole hydrochloride (SKF-101468A) is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with anti...		Dopamine Receptor